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5 The measurement of cotinine--a primary metabolite of nicotine with a half-life of 16 to 18 hours that is detectable in urine, saliva, or serum--is a reliable method of determining use of or exposure to cigarettes or other tobacco products over a period of 2 to 3 days

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Clinical data indicate that smoking adversely affects multiple aspects of liver disease, including the incidence and severity of hepatic steatosis, progression of fibrosis, development of HCC, and outcomes among alcohol-related liver transplant recipients [78, 79]